Discover the therapeutic application of St. John’s Wort for Depression

Published by wellsome.co.nz on 17 June 202317 June 2023

Depression is a complex mental health condition, and St. John’s Wort (Hypericum perforatum) has been extensively studied as a natural antidepressant. Research has included various trial types, age groups, and comparisons with placebos and antidepressants. The antidepressant effects of St. John’s Wort are believed to be attributed to several mechanisms and constituents.

Several studies, including meta-analyses, have found that St. John’s Wort is comparable in effectiveness to selective serotonin reuptake inhibitors (SSRIs) for patients with mild-to-moderate depression. It has been shown to improve depressive symptoms as measured by rating scales such as the Hamilton Rating Scale (HRS).

One of the advantages of the herb compared to traditional antidepressant medications is its lower incidence of side effects. Studies have reported fewer adverse reactions and a lower dropout rate among patients using St. John’s Wort. This can be particularly beneficial for individuals who are sensitive to the side effects of conventional antidepressants.

Although evidence for long-term use of St. John’s Wort is limited, it has been suggested that the herb may have therapeutic value over an extended period. Some studies have shown that its effects  can be maintained over time, indicating its potential for long-term treatment of depression.

St. John’s Wort is generally considered safe when used as a standalone treatment for depression. However, it is important to note that the herb can interact with certain medications by inducing cytochrome P450 enzymes and P-glycoprotein transporters. These interactions can affect the efficacy of other drugs metabolised by these enzymes and may require careful monitoring and adjustment of medication regimens.

It is important to note that while St. John’s Wort has shown promising results in depression, individual responses may vary. Additionally, it is recommended to use St. John’s Wort under the guidance of a healthcare professional, especially if you have any underlying health conditions or are taking medications. They can provide personalised recommendations on dosage, duration, and potential interactions to ensure safe and effective use.